Friday, December 4, 2009

Combat Zone
















I love coming across published gems with a sense of humor.
Found this one by Jencks in Chem. Soc. Rev., 1981, 10, 345-375

It's a depiction of the dichotomous SN1/SN2 mechanisms and examples of borderline reactions in the "COMBAT ZONE." The defining feature of borderline reactions are those which show intermediate order in the nucleophile. SN1 reactions should show a rate independent of nucleophile concentration. SN2 reactions should show a rate directly dependent on the nucleophile concentration. Stuff in the middle can be explained as concurrent SN1 and SN2 reactions or as proceeding through some other scheme of intermediates.

Being in a synthetic organic lab, I'm not a fan of anything less than SN2. Why on Earth would I want racemization?!

No comments: